The special issue consists of more than 70 articles which include invited review articles from pioneering research groups, as well original scientific articles and reviews submitted in response to the call for papers ( Fig. At this quarter century mark, it is appropriate to take stock of this burgeoning technology by the collection of original, review, and historical articles in this special issue of Investigative Ophthalmology & Visual Science. Advances in OCT technology itself, as well as fundamental scientific and industrial applications, are also active areas of research. The growth in many other medical specialties has also become significant in the past few years, particularly in the fields of cardiovascular imaging (i.e., coronary intravascular OCT), dermatology, and gastroenterology. It is estimated that there are now ∼30 million OCT imaging procedures performed worldwide every year. In the past decade, OCT has been the most commonly used ophthalmic imaging procedure by far. Ophthalmic applications have developed the earliest, and continue to be the primary area of research and clinical application for OCT. The role of OCT in research and clinical care continues to accelerate, as judged by the cumulative number of publications in scientific journals ( Fig. OCT has had a transformative impact in the field of ophthalmology and vision research, contributing to fundamental understanding of disease pathogenesis, drug discovery and development, and everyday clinical decision making in all ophthalmic subspecialties. This special issue commemorates the 25th anniversary of the development of optical coherence tomography (OCT).
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